The present invention is directed to novel indole derivatives, pharmaceuticalcompositions containing them and their use in the treatment or prevention ofdisorders and diseases mediated by agonists and antagonists of theprogesteronereceptor. The clinical uses of these compounds are related to contraception,thetreatment and/or prevention of secondary amenorrhea, dysfunctional bleeding,uterine leiomyomata, endometriosis； polycystic ovary syndrome, carcinomas andadenocarcinomas of the endometrium, ovary, breast, colon, prostate, orminication ofside effects of cyclid menstrual bleeding. Additional uses of the inventionincludestimulation of food intake.
