Modified K562 cells having reduced expression of MHC class I as compared to wildtype K562 cells are disclosed. Also disclosed are articles and methods for producing such modified K562 cells, and methods using such modified K562 cells.本發明揭示與野生型K562細胞相比具有降低之MHC I類表現的經修飾之K562細胞。亦揭示用於產生此類經修飾之K562細胞的製品及方法,及使用此類經修飾之K562細胞的方法。