CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人:
NAM, Suk Woo,남석우
申请号：
KRKR2011/002031
公开号：
WO2011/118994A3
申请日:
2011.03.25
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a novel marker for the diagnosis of liver cancer and the use thereof. More specifically, the present invention relates to a marker for the diagnosis of liver cancer, using NLK (nemo like kinase) by confirming the overexpression of the NLK in the liver cancer cells, and to a composition, a kit, a microarray, and a method for the diagnosis of liver cancer using the marker. The present invention also relates to a method for screening a substance that can prevent or treat liver cancer by reducing the expression of a marker gene or a protein, and to a composition for preventing or treating liver cancer, which includes said substance. According to the present invention, NLK, which is the marker gene for liver cancer, has an unusually increased amount of expression in the liver cancer tissues compared to the normal liver tissues, and thus suppressing the expression of said gene reduces the expression of cyclin D1 and CDK2 in liver cancer cells, suppresses the progression of a cell cycle in stage G1/S, and at the same time, restrains the proliferation of the cells, thereby effectively preventing or treating liver cancer. Therefore, the NLK gene discovered in the current invention can be usefully used as a target for the diagnosis and the treatment of liver cancer.La présente invention concerne un nouveau marqueur pour le diagnostic du cancer du foie et son utilisation. Plus particulièrement, la présente invention concerne un marqueur pour le diagnostic du cancer du foie, au moyen de la protéine NEMO (NLK) par confirmation de la surexpression de NLK dans les cellules cancéreuses du foie, et une composition, une trousse, une puce à ADN, ainsi quun procédé pour le diagnostic du cancer du foie mettant en œuvre le marqueur. La présente invention concerne également un procédé permettant le criblage dune substance capable de prévention ou de traitement du cancer du foie par la réduction de lexpression dun gène marqueur ou dune protéine, et une comp
