AGUILAR RUBIDO, JULIO CESAR,LOBAINA MATO, YADIRA,IGLESIAS PEREZ, ENRIQUE,PENTON ARIAS, EDUARDO,GUILLEN NIETO, GERARDO ENRIQUE,AGUIAR SANTIAGO, JORGE AGUSTIN,GONZALEZ BLANCO, SONIA,VALDES HERNANDEZ, JO
申请号：
CA3017778
公开号：
CA3017778A1
申请日:
2017.03.14
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to a pharmaceutical composition comprising the surface antigen (HBsAg) of the hepatitis B virus (HBV) and the antigen of the nucleocapsid (or core, HBcAg) of the same virus. The HBcAg of this composition contains messenger ribonucleic acid (mRNA) at a proportion of over 45% of the total amount of ribonucleic acid (RNA) in this antigen. Because of the changes in the constitution of the constituent antigens, the composition of the invention is suitable for use for the prevention or treatment of chronic hepatitis B. The invention also relates to the use of this pharmaceutical composition in the production of a drug for immuno-prophylaxis or immunotherapy against HBV infection, and to its use to increase the immune response against an additional antigen that is co-administered with the mixture of these antigens.
