CALIFORNIA INSTITUTE OF TECHNOLOGY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
BALTIMORE, DAVID,QIN, XIAO-FENG,LOIS-CABALLE, CARLOS,CHEN, IRVIN S. Y.,AN, DONG SUNG
申请号：
CA2952590
公开号：
CA2952590C
申请日:
2002.09.13
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
In ones aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or viral replication in a host cell. In another aspect, the invention provides methods for treating patients suffering from infection, particularly infection with HIV.
