ABSTRACT TITLE: SYSTEM AND KIT FOR MONITORING BLOOD GLUCOSE PROFILE BASED ON BREATH ANALYSIS A system and kit comprising said system is provided for monitoring blood glucose profile of a subject in real time and in a non- invasive manner depending on 13CO2/12CO2 stable isotope ratios of the subject�s exhaled breath comprising exhaled breath sample collector cooperative user interface means operatively connecting said exhaled breath sample collector inputs to computing means said computing means provided to enable simultaneous monitoring and measurement of 13CO2 and 12CO2 based on said exhaled breath sample receiver and computing in real-time in subjects for measuring pre-dose (basal) and 13C- glucose test meal post-dose exhaled breath and generating 13CO2 /12CO2 isotopes ratio and/or said CO2 recovery rate and involving the same in quantifying the blood glucose level at different time intervals to thereby favour monitoring of blood glucose profile and detecting diabetic condition of a subject based on (i) concentration of exogenous labelled glucose and (ii) evaluating concentrations of glucose selectively in insulin dependent and non-insulin dependent pathways/compartment associated with glucose metabolism of the subject. Advantageously, the system and kit of present invention can also precisely and selectively diagnose whether a person is normal, pre- diabetes or type 2 diabetes using breath analysis. Fig.6
