The present invention discloses a block copolymer having a hydrophobic block, a hydrophilic block, and a biologically active block. The biologically active block is directly adjacent to the hydrophilic block. Preferably, the block copolymer is prepared through reversible addition fragmentation transfer (RAFT) polymerization. The present invention also discloses a coating composition comprising the inventive block copolymer. The coating composition may be used for applying on at least a portion of one surface of an article. Moreover, the present invention discloses an article having the inventive coating composition thereon. Preferably, the article is a medical device or a component of a medical device.
