Regeneron Pharmaceuticals, Inc.;Yale University;Institute for Research in Biomedicine (IRB)
发明人:
Flavell Richard,Strowig Till,Manz Markus G.,Borsotti Chiara,Dhodapkar Madhav,Murphy Andrew J.,Stevens Sean,Yancopoulos George D.
申请号：
US201615192903
公开号：
US9986724(B2)
申请日:
2016.06.24
申请国别(地区):
美国
年份:
2018
代理人:
Smeland Tor`Gont Ilona`Rubin Michael B.
摘要：
Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.
