Macrocyclic compounds derived from Proline, Serine proteases inhibitors of hepatitis C virus (HCV)； Pharmaceutical composition that comprises； and its use to treat a viral infection such as the infection by the hepatitis C virus (HCV).
OR YAT SUN,WANG BIN,MA JUN,WANG GUOQIANG,LONG JIANG
申请号：
CL2014000612
公开号：
CL2014000612A1
申请日:
2014.03.13
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.<；p>；COMPUESTOS DERIVADOS DE PROLINAS MACROCICLICAS, INHIBIDORES DE LA PROTEASA DE SERINA NS3 NS4A； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； Y SU USO PARA TRATAR UNA INFECCION VIRAL TAL COMO LA INFECCION POR EL VIRUS DE LA HEPATITIS C (VHC).<；/p>；
