A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human TNF-like ligand 1A (hTL1A) is provided. The human anti-hTL1A antibodies are useful in treating diseases or disorders associated with TL1A, such as inflammatory diseases or disorders, e.g., inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, rheumatoid arthritis, and the like; autoimmune diseases or disorders, such as multiple sclerosis, diabetes, and the like; and allergic reactions, such as asthma and allergic lung inflammation.ヒトTNF様リガンド1A(hTL1A)に特異的に結合し阻害する完全ヒト抗体またはヒト抗体の抗原結合性断片が提供される。ヒト抗hTL1A抗体は、炎症性疾患または障害、例えば潰瘍性大腸炎およびクローン病を含めた炎症性腸疾患、関節リウマチなど;自己免疫疾患または障害、例えば多発性硬化症、糖尿病など;ならびにアレルギー反応、例えば喘息およびアレルギー性肺炎症などのTL1Aと関連する疾患または障害の治療において有用である。