Problem to be solved: to provide an internal probiotics spherical tablet capable of increasing the environmental performance and stability by the multilayer coating structure and having resistance to acids, bile salts and pancreatic juice in the digestive tract, and producing a mass production at a low cost.Solution: an acid resistant and sustained release internal probiotics spherical tablet covers the core 1 containing probiotics, the protective layer 2 covering the outer side of the core 1, the retarded release layer 3 covering the outer side of the protective layer 2, the anti bile acid saline pancreatic liquid layer 4 covering the outside of the gradual release layer 3, and the outer layer of the biliary acid saline pancreatic liquid layer The acid layer 5 and the isolation layer 6 covering the outside of the acid resistant layer 5.Core 1 containing probiotics is formed into a spherical core.Diagram【課題】多層被覆構造により耐環境性能及び安定性を高め、消化管内で酸、胆汁酸塩、膵液などに対する耐性を有し、安価に大量生産することができる、内服プロバイオティクス球状錠剤を提供する。【解決手段】耐酸性・徐放性の内服プロバイオティクス球状錠剤は、プロバイオティクスを含むコア１と、コア１の外側を覆う保護層２と、保護層２の外側を覆う徐放層３と、徐放層３の外側を覆う耐胆汁酸塩膵液層４と、耐胆汁酸塩膵液層４の外側を覆う耐酸層５と、耐酸層５の外側を覆う隔離層６とを含む。プロバイオティクスを含むコア１は球形コアに成形される。【選択図】図１
