XU GE,LV BINHUA,SEED BRIAN,XU BAIHUA,ROBERGE JACQUES
申请号：
NZ63040813
公开号：
NZ630408A
申请日:
2013.03.14
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter (SGLT) and synthetic intermediates useful for preparing such compounds. The synthesis involves the use of a Grignard reagent to prepare compounds such as: (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-cyclopropylbenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol and (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.
