591818 Disclosed is a method for producing a complex of formula IA which is an amino acid salt of a pyran. The method includes reacting the precursor with a reducing agent in the presence of an activating group to form the compound and then reacting it with an amino acid to form the complex of formula IA. Examples of the compounds are: (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-(2,2,2- trifluoroethoxy)ethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol； (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-(cyclohex-2-enyloxy)ethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol； and (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((E)-3-cyclopropylallyloxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol complexed with proline or phenylalanine.
