您的位置: 首页 > 农业专利 > 详情页

Derivatives of indenocarboxylic acids and their use for the treatment and prevention of diabetes and dyslipidemia
专利权人:
Merck Patent GmbH
发明人:
ADJE, Nathalie,BRUNET, Michel,ROCHE, Didier,ZEILLER, Jean-Jacques,YVON, Stéphane,GUYARD-DANGREMONT, Valérie,CONTARD, Francis,GUERRIER, Daniel,FERRAND, Gérard,BONHOMME, Yves
申请号:
ES03785831
公开号:
ES2636992T3
申请日:
2003.12.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of the formula I: ** Formula ** in which: n is an integer chosen between 1, 2 and 3; Y represents O; N-OR9, wherein R9 represents H or a saturated hydrocarbon-based aliphatic group; CR10R11, wherein R10 and R11, which may be identical or different, represent H or a saturated hydrocarbon-based aliphatic group; R1, R2, R3 and R4 are independently selected from a hydrogen atom and alkyl; R5 represents Z; R6 represents W; Z represents alkyl optionally substituted with one or more radicals T; alkenyl optionally substituted with one or more T radicals; alkynyl optionally substituted with one or more T radicals; phenyl optionally substituted with one or more T radicals; cycloalkyl optionally substituted with one or more T radicals; monocyclic or bicyclic heteroaryl optionally substituted with one or more T radicals; -alk1-Cy1, wherein alk1 represents alkylene, preferably CH2 and Cy1 represent phenyl optionally substituted with one or more T radicals, or alternatively Cy1 represents cycloalkyl, optionally substituted with one or more T radicals; T being selected from optionally halogenated alkyl; optionally halogenated alkoxy; a halogen atom; and cyano; W represents -XL-CO2R7; -X-L-Tet, in which X and L are as defined below and Tet represents tetrazole; wherein L represents an alkylene, alkenylene or -alk ° -Ar ° - group, in which alk represents alkylene and Ar ° represents phenylene; X represents O; NR8, in which R8 represents H; a group based on saturated aliphatic hydrocarbon; a group -COR 'or -SO2-R', in which R 'takes any of the meanings given below for R7 with the exception of H; or R8 represents an aromatic carbocyclic group; or X represents S (O) m, in which m is chosen between 0, 1 and 2; R7 represents H or alkyl; and pharmaceutically acceptable salts, solvates and stereoisomers thereof, and also mixtures thereof in all proportions.Compuestos de la fórmula I:**Fórmula** en la que: n es un entero elegido entre 1, 2 y 3; Y representa O; N-OR9, en el que R9
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充