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COMBINATION COMPRISING A BTK INHIBITOR AND AN AKT INHIBITOR
专利权人:
NOVARTIS AG
发明人:
KUMAR, RAKESH,ROBELL, KIMBERLY A.
申请号:
CA2942204
公开号:
CA2942204A1
申请日:
2015.02.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
A novel combination comprising a BTK inhibitor, for example: 1-[(3R)-3-[4-amino- 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one or a pharmaceutically acceptable salt thereof, and an AKT inhibiting compound, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H- pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which BTK inhibition and/or AKT inhibition is beneficial, e.g., cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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