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Povidone iodine, a novel alternative preservative for ophthalmic compositions
专利权人:
FORESIGHT BIOTHERAPEUTICS INC.
发明人:
Liang, Bo,Samson, C. Michael,Stein, Jason,Weiser, Michael,Capriotti, Joseph A.
申请号:
NZ73152409
公开号:
NZ731524A
申请日:
2009.06.10
申请国别(地区):
NZ
年份:
2018
代理人:
摘要:
Disclosed herein is an stable ophthalmic composition suitable for topical administration to the eye, comprising a mixture of: (a) povidone-iodine (PVP-I) at a concentration between 0.01% and 10%, and (b) a steroid, wherein the steroid is dexamethasone sodium phosphate or dexamethasone alcohol, wherein the pH of the composition is in the range of 3 to 4. Said stable ophthalmic composition may further comprises an antimicrobial preservative selected from the group consisting of benzalkonium chloride, thimerosal, chlorobutanol, methyl paraben, propyl paraben, phenylethyl alcohol, EDTA, sorbic acid, polyquarternium 1, and any combination thereof a viscosity increasing agent selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, methyl cellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, hydroxypropylcellulose, and any combination thereof a co-solvent/surfactant is selected from the group consisting of polysorbate 20, polysorbate 60, polysorbate 80, poloxamer 188, poloxamer 234, poloxamer 333, cyclodextrin, tyloxapol and a combination thereof and artificial tears-based lubricant.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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