Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.L'invention concerne des composés, des compositions et des méthodes pour le traitement de maladies et de troubles associés au cancer, comprenant des tubulysines et des conjugués médicamenteux protéiques (par ex., anticorps) associés. <;i />;