An orthopedic cock-up wrist brace and splint for people with arthritis, carpal tunnel syndrome, sprains, fractures, tendonitis, repetitive strain injury, osteoporosis, or other wrist injury. The splint having a specially designed hourglass shape formed using medical fit data in addition to established sizing data and refined after comprehensive studies and testing. The splint supplied as a stand-alone product or as part of a wrist brace system.