Disclosed herein are humanized antibodies, anti gen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.於此係揭示一種人源化抗體、其抗原結合片段，以及抗體共軛物，其可特異性地結合至某些雙觸角Lewis抗原，該抗原係於多種癌症中表現。本發明揭示可用於靶向抗原-表現細胞之抗體，用於治療或偵測疾病，包括各種癌症。亦提供用於製造所揭示之抗體與其抗原結合片段之聚核苷酸、載體與宿主細胞。亦提供該醫藥組成物、治療與偵測方法，以及該抗體、抗原結合片段、抗體共軛物與組成物之用途。
