Robert B. Perni,Youssef Bennani,Gregor Zlokarnik,Gerald J. Tanoury,Minzhang Chen,Young Chun Jung,Raymond E. Forslund,Francois Maltais
申请号:
US12953876
公开号:
US08247532B2
申请日:
2010.11.24
申请国别(地区):
US
年份:
2012
代理人:
摘要:
This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1wherein the variables R1,R′1 and R′2 are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.