Binder, Jeffrey R.,Higgins, Joel C.,Leach, Michael D.,OShaughnessey, Krista,Woodell-May, Jennifer E.
申请号：
AU2014238305
公开号：
AU2014238305A1
申请日:
2014.02.18
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets.
