Jeffrey R. Binder,Joel C. Higgins,Michael D. Leach,Krista Toler,Jennifer E. Woodell-May
申请号：
US15885432
公开号：
US20180243376A1
申请日:
2018.01.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor； (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist； and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. Compositions may also contain white blood cells and platelets.
