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DÉRIVÉ D'OXAZINE ET INHIBITEUR DE BACE 1 LE CONTENANT
专利权人:
LTD.;SHIONOGI & CO.
发明人:
MASUI, MORIYASU,MITSUOKA, YASUNORI,YOSHIDA, SYUHEI,KUSAKABE, KEN-ICHI,ONODERA, NAOHIRO,KUROSE, NORIYUKI
申请号:
EP12777494
公开号:
EP2703399A4
申请日:
2012.04.25
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention provides a compound of formula (I): wherein -X= is -CR 7 = or -N=, ring B is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, R 1 is substituted or unsubstituted alkyl or the like, R 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R 3 and R 4 are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, R 5 is hydrogen, substituted or unsubstituted alkyl or the like, each R 6 is independently halogen, hydroxy, substituted or unsubstituted alkyl or the like, R 7 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid ² production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ² proteins.
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