An instrument cassette (100, 200, 300) for handling instruments comprises a body section (101, 201, 301) for holding the instruments and a radio frequency identifier (102, 202, 302) readable from a distance away from the instrument cassette (100, 200, 300). The radio frequency identifier (102, 202, 302) of the instrument cassette (100, 200, 300) facilitates tracing operations, such as for example disinfection, sterilization, reparation, and clinical use, directed to or carried out with a set of instruments handled with the aid of the instrument cassette (100, 200, 300). The instruments can be for example medical and/or dental hand instruments.