A safety scalpel incorporating a handle similar in thickness, length, weight, balance, shape and feel to the conventional metal handle preferred by most surgeons, and a disposable cartridge assembly that is easily mounted and released from the scalpel handle. The handle comprises a first end and a second end. The cartridge assembly comprises a blade guard/shield that can be slideably mounted onto the second end of the handle, a blade holder/slider that can be disposed within the blade guard, and a blade that can be attached to the blade holder. The safety scalpel incorporates a locking system that prevents the cartridge assembly from sliding off or wobbling on the handle during use.一種安全手術刀,結合有:握柄,其厚度、長度、重量、平衡、形狀、及觸感類似於大多數外科醫生所喜愛的習知金屬握柄;以及,可拋棄式的匣體總成,能夠輕易地安裝到手術刀握柄,並自其上移除。握柄包含第一端及第二端。匣體總成包含:可滑動地安裝於握柄之第二端上的刀片護具/護罩、可放置在刀片護具內的刀片支架/滑動件、及裝附至刀片支架的刀片。此種安全手術刀結合有鎖合系統,防止匣體總成在使用期間從握柄上滑脫或產生搖晃。100...(安全)手術刀200...(手術刀)握柄201...縱向軸線202...第一端204...第二端210...握持部212...指標;刻度220...鎖合部230...卡合部232...(上升)斜面234...切口236...(縱向)溝槽;鍵槽238...(防搖晃)棘爪;凸塊240...孔洞242...(削尖狀)尖端300...匣體總成;(刀片)外殼400...護罩;(刀片)護具402...凹穴404...第一端406...第二端407...第一開口409...第二開口410...鎖合按扣;垂片420...狹縫422...滑動件分離端;開口;狹縫424...滑動件卡合端;開口;狹縫425...延伸部430...抓握部440...位置指標;伸出構件450...(滑動件)鎖合孔洞500...滑動件;(刀片)支架504...刀片棘爪506...柄容納孔洞510...(前)腿部;前腿520...(後)腿部;後腿522...前腳524...前腳526...後腳528...後腳600...刀片602...(刀片)尖端604...切割邊緣606...滑動件孔洞700...按鈕;致動構件704...(按鈕)頭部705...隆起