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2-胺基-2苯基-烷醇,其製造方法,以及含此化合物之醫藥組成物
专利权人:
DENIS ALEXIS;OROXCELL
发明人:
PACHOT, JEAN,博舒特 杰恩,博舒特 傑恩,DINI, CHRISTOPHE,迪尼 克理斯多夫,DENIS, ALEXIS,德尼斯 艾力克斯,博舒特 杰恩,博舒特 傑恩,迪尼 克理斯多夫,德尼斯 艾力克斯
申请号:
TW098101864
公开号:
TWI393561B
申请日:
2009.01.19
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R1is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2is a -CO-R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or R2is a -CO-Y-R4radical for which Y is -O-, -S-, -NH-, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and R4is alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by R5COO- in which R5is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or R2is alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-member heterocycle optionally having another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least 2C between >;N-R2and the substituent; and R3is alkyl (1 to 4C) straight or branched unless specifically mentioned, alkyl or acyl are straight or branched (1 to 7C), in their R or S forms or their mixtures, as well as their pharmaceutically acceptable salts when these exist.通式為(I)的2-胺基-2苯基-烷醇(2-amino-2-phenyl-alkanol)酯衍生物,其中:R1係氫原子(hydrogen atom)、含有直或支鏈之1至4個碳原子的烷基自由基(alkyl radical)或含有直或支鏈之2至4個碳原子的烷基自由基(alkyl radical),由羥基(OH)、烷氧基(alkoxy)、烷巰基(alkylthio)、醯氧基(acyloxy)、胺基(NH2)、烷胺基(alkylamino)、二烷基胺基(dialkylamino)、烷胺甲醯基氧基(alkylcarbamoyloxy)、烷氧基羰基胺基(alkoxycarbonylamino)、脲基(ureido)
来源网站:
中国工程科技知识中心
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