#$%^&*AU2017100368A420170518.pdf#####H: grs Interwoven NRPortbl DCC GRS 13743890_.doex-3 1/03/20 7 Abstract Provided herein are methods for improving cerebrovascular function and cognitive performance, and for preventing or reducing cognitive or memory impairment or decline, in peri-menopausal and post-menopausal human subjects, comprising the administration of an effective amount of resveratrol. Also provided are methods for treating pain, tension and anxiety associated with menopause and related conditions such as osteoarthritis, comprising the administration of an effective amount of resveratrol.