DIANNA L. AMBROSE,JAEHONG LEE,NEIL T. SCHOLL,VASILY A. TOPOLKARAEV,YOUNGSOOK KIM
申请号：
BR112013013880
公开号：
BR112013013880A2
申请日:
2011.10.31
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
process for forming an antimicrobial composition, antimicrobial composition processed as a melt, tissue and process for removing bacteria from a surface The present invention provides a process for forming an antimicrobial composition, which includes mixing an antimicrobially botanical oil active (eg thymol, carvacrol, etc.) and protein within a melt blending device (eg extruder). Despite the problems normally associated with fusion mass processing proteins, the present inventors have found that the processing conditions and components can be selectively controlled to allow the formation of a stable, fusion mass processed composition that is capable of exhibiting Good mechanical properties. for example, the extrusion temperatures and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thus minimizing the impact of aggregation and embrittlement. While the use of such low temperature / shear conditions often tends to reduce mixing efficiency, the present inventors have found that carrier fluid can be employed to enhance the ability of botanical oil to flow into the internal structure of the protein in which it is present. can be stably retained. Typically, the composition is generally also anhydrous and solvent free. In this way, the protein will not generally disperse before use and prematurely release the botanical oil.processo para formação de uma composição antimicrobiana, composição antimicrobiana processada como massa em fusão, lenço e processo para remoção de bactérias a partir de uma superfície a presente invenção provê um processo para formação de uma composição antimicrobiana, que incluir a misturação de um óleo botânico antimicrobianamente ativo (por exemplo, timol, carvacrol, etc.) e proteína dentro de um dispositivo de combinação de massa em fusão (por exemplo, extrusora). apesar dos problemas normalmente associados com proteínas em processamento de massa em fusão, os presentes inventores constataram que as
