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COMPOUND OF ADENINE 31/14 A61P 31/16 A61P 31/18 A61P 31/20 A61P 31/22 A61P 33/02 A61P 35/00 A61P 35/02 A61P 35/04 A61P 37/00 A61P 37/02 A61P 37/08 A61P 43/00 C07D 473/16 C07D 473/18
专利权人:
ASTRAZENECA AKTIEBOLAG;DAINIPPON SUMITOMO PHARMA CO., LTD.
发明人:
YOSHIAKI ISOBE,TOMOAKI NAKAMURA
申请号:
BRPI0809134
公开号:
BRPI0809134A2
申请日:
2008.03.19
申请国别(地区):
BR
年份:
2014
代理人:
摘要:
A novel adenine compound represented by the formula (1): wherein A represents an (un)substituted aromatic carbocycle or (un)substituted aromatic heterocycle; L 1 and L 2 each independently represents straighted or branched alkylene, etc.; R 1 represents halogen, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, (un)substituted aryl, or (un)substituted heteroaryl; R 2 and R 3 each independently represents hydrogen, or (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, (un)substituted saturated heterocycle, (un)substituted aryl, or (un)substituted heteroaryl, or R 2 combines together with L 2 or R 3 to form (un)substituted 4- to 8-membered nitrogen-containing saturated heterocycle; X is oxygen, sulfur, SO, SO 2 , NR 7 , NR 7 CO wherein R 7 is hydrogen or alkyl, or a single bond; provided that X is a single bond when R 1 is halogen, or a pharmaceutically acceptable salt thereof. The compound and salt are useful as a medicine.
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