DERIVES DE PHOSPHONATE ET DE PHOSPHINATE EN TANT QU'ACTIVATEURS DE LA GLUCOKINASE

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

申请号：

EP07812578.8

公开号：

EP2059522B1

申请日:

2007.07.03

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Pyrazoloamides are provided which are phosphonate and phosphinate glucokinase activators that are useful in treating diabetes and related diseases and have the structure wherein is a pyrazolyl ring； R4 is &mdash；(CH2)n&mdash；Z&mdash；(CH2)m&mdash；PO(OR7)(OR8), &mdash；(CH2)nZ&mdash；(CH2)m&mdash；PO(OR7)R9, or &mdash；(CH2)nZ&mdash；(CH2)m&mdash；PO(R9)(R10)； R5 and R6 are independently selected from H, alkyl and halogen； Y is R3(CH2)s, wherein R3 is aryl, s is 0, X is a bond； and n, Z, m, R4, R5, R6, and R7 are as defined herein； or a pharmaceutically acceptable salt thereof.

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