AMANS DOMINIQUE,ATKINSON STEPHEN JOHN,HARRISON LEE ANDREW,HIRST DAVID JONATHAN,LAW ROBERT PETER,LINDON MATTHEW,PRESTON ALEXANDER,SEAL JONATHAN THOMAS,WELLAWAY CHRISTOPHER ROLAND
申请号：
IN2676/KOLNP/2015
公开号：
IN2015KN02676A
申请日:
2015.08.13
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to novel compounds of formula (I), wherein R1 is C1-4alkyl； R2 is C1-4alkyl, C3-7cycloalkyl, -CH2CF3, -CH2OCH3 or heterocyclyl； R3 is C1-4alkyl, -CH2F, -CH2OH or -CH2O(O)CH3； R4 when present is as defined in claim 1； R5 when present is H, halo, hydroxy or C1-6alkoxy； A is -NH-, -O-, -S-, -SO-, -SO2-, -N(C1-4alkyl)- or -NC(O)(CH3)-； V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents； W is CH or N； X is C or N； Y is C or N； and Z is CH or N； subject to the proviso that no more than 2 of W, X, Y and Z are N, pharmaceutical compositions containing such compounds and to their use as bromodomain inhibitors.
