DENIS, JEAN-NOËL,JOLIVALT, CLAUDE MARCELLE,MAURIN, MAX MAURIN LOUIS,JEANTY, MATTHIEU
申请号：
ES11305963
公开号：
ES2464598T3
申请日:
2011.07.22
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compounds of the following formula I: ** ** Formula in which: X represents O or S, R1, R2, R3, R4, R5, R1, R2, R3, R4 and R 5 represent independently: - H, - (C1-C7) alkyl, if appropriate 1sustituido with: halogen, hydroxyl, ORa or NRaRb, where Ra and Rb represent H, a (C1-C7) alkyl, cycloalkyl (C3-C7) a substituted or unsubstituted aryl, CH2-aryl, CO (C1-C7), CO-aryl, CO2-alkyl (C1-C7) , CO2-aryl, wherein aryl is an aromatic group, substituted or unsubstituted, or a heteroaromatic group, substituted or - cycloalkyl (C3-C7), substituted or unsubstituted aryl, CH2-aryl, CO-alkyl (C1 C7), CO-aryl, CO2-alkyl (C1- C7), CO2-aryl, wherein aryl is an aromatic group, substituted or unsubstituted, or a substituted or unsubstituted heteroaromatic group, - F, Cl, Br, I , CF3, OH, OCF3, COCF3, ORa, NH2, NHR, NRaRb, wherein Ra and Rb represent H, a (C1-C7) alkyl, cycloalkyl (C3-C7), or substituted aryl n or not, CH2-aryl, CO30 (C1-C7), CO-aryl, CO2-alkyl (C1-C7), CO2-aryl, wherein aryl is a substituted or unsubstituted aromatic group or a heteroaromatic group substituted or not, - CN and NO2, with the proviso that R1, R2, R3, R4, R5, R1 are different from CN and NO2. R represents H, a (C1-C7), CH2NHCO2-alkyl (C1-C7), CH2NHCO2-cycloalkyl (C3-C7), CO2H, CO2- (C1-C7), CO2 (C3-C7), (CH2) nOH, CH2NH (CH2) nOH, CH2NH (CH2) n-NRaRb, CONH (C1-C7) CONH (C3-C7), CONH-aryl, CONH (CH2) nOH, CONH- (CH2) nNRaRb, where n> = 2 to 12, and where Ra, Rb, aryl and alkyl as defined above. R6 and R6, independently of one another H, (C1-C7) SO2arilo, wherein aryl is as defined above, OH, O-alkyl (C1-C7), CO-alkyl- (C1-C7 ), CO-aryl, CH2NH2, CH2NHRa, CH2NRaRb, CH2NRaRb, Si (Rc) 3 wherein the R groups are identical or different and represent, independently, a (C1-C7) alkyl, cycloalkyl (C3 C7), or an aryl, with aryl and alkyl as defined above, R7 represents H, OH, ORa, where Ra is as defined above. and pharmaceutically acceptable salts thereof, for use as a medicament suitable for antibacterial activity
