Tord Bertil INGHARDT,Petra JOHANNESSON,Ulrik JURVA,Erik MICHAELSSON,Eva-Lotte LINDSTEDT-ALSTERMARK,Nicholas TOMKINSON,Jeffrey Paul STONEHOUSE,Li-Ming Gan
申请号：
US15454318
公开号：
US20170173025A1
申请日:
2017.03.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I),and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
