1. The use of a variant of the initial defensin containing a substitution in one or more positions corresponding to the provisions of 5, 9, 11, 13, 14, 17, 20, 23, 26, 31, 36 and 38 of the mature polypeptide with the sequence SEQ ID NO: 2, for the manufacture of a medicament for the treatment of diseases caused by Mycobacterium, for example tuberculosis； moreover, this option is able to destroy or inhibit Mycobacterium tuberculosis cells； and where the starting defensin is a polypeptide containing an amino acid sequence that is at least 90% identical to a mature polypeptide with the sequence SEQ ID NO: 2 or a polypeptide encoded by a polynucleotide that hybridizes under high stringency conditions to a sequence encoding a mature polypeptide with the SEQ sequence ID NO: 1, or its complementary chain. ! 2. The use according to claim 1, wherein the starting defensin is a polypeptide containing an amino acid sequence that is 95% identical to the mature polypeptide with the sequence SEQ ID NO: 2, preferably where the starting defensin contains or consists of a mature polypeptide with the sequence SEQ ID NO: 2. ! 3. The use according to claim 1, where the replacement in the position corresponding to! position 5, represents Gly, Ser or Arg； ! position 9, represents Gly, Ser or Asn； ! position 11 represents Asn or Gly； ! position 13, represents Leu, Val or Lys； ! position 14, represents Leu, Phe, Lys or Arg； ! position 17, represents Val or Gln； ! position 20 represents Arg； ! position 23 represents Arg； ! position 26 represents Arg； ! position 31, represents Ser or Thr； ! position 36 represents1. Применение варианта исходного дефенсина, содержащего замену в одном или нескольких положениях, соответствующих положениям 5, 9, 11, 13, 14, 17, 20, 23, 26, 31, 36 и 38 зрелого полипептида с последовательностью SEQ ID NO:2, для получения лекарственного средства для терапии заболеваний, вызываемых Mycobacterium, например туберкулеза； причем указанный вариант способен уничтожать или и
