Immunotherapy with binding agents

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专利权人:

ONCOMED PHARMACEUTICALS INC.

发明人:

GURNEY AUSTIN L.,AXELROD FUMIKO TAKADA

申请号：

NZ70905913

公开号：

NZ709059A

申请日:

2013.12.04

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Binding agents that specifically bind the extracellular domain of human TIGIT and methods of use are disclosed. The binding agents may comprise a soluble poliovirus receptor (PVR) variant with one or more amino acid substitutions as compared to wild-type PVR. Binding agents may specifically bind the extracellular domain of human TIGIT and do not bind or bind weakly to the extracellular domain of human CD226, which can be used in the methods for the treatment of diseases such as cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/