Fernando Alberto GOLDBAUM,Vanesa ZYLBERMAN,Patricio Oliver CRAIG,Giselle GHERSI,Marina Sandra PALERMO,Maria Pilar MEJIAS,Leticia Veronica BENTANCOR
申请号：
US14894484
公开号：
US20160115459A1
申请日:
2014.05.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Chimeric polypeptides useful as immunogens for inducing protective immune responses and neutralizing antibodies against Shiga toxin (Stx) in mammals. More specifically, chimeric polypeptides having a monomer of the homopentameric B subunit of the Shiga 2 toxin fused to the N-terminus of a monomer of Brucella lumazine synthase, and to oligomeric protein complexes formed from said chimeric polypeptides. Polynucleotides and vectors encoding said chimeric polypeptides, transgenic cells having said polynucleotides and vectors, pharmaceutical compositions, such as a vaccine, having said chimeric polypeptides and chimeric polynucleotides, antibodies which bind to the chimeric polypeptides, a method for obtaining antibodies which bind specifically to the subunit B of the Shiga 2 toxin and methods of lowering the bacterial load of enterohemorrhagic Escherichia coli in mammals, which can be used for prevention of inter cilia, hemolytic-ureic syndrome (HUS), are also provided.
