The invention discloses a nanoparticle composition.The nanoparticle compositions generally comprise at least one, preferably two or more active agents, one of which is an immunomodulatory compound loaded into, attached to, and / or enclosed within the transfer agent.These transfer agents can be nano liposome gel or biodegradable polymeric nanoparticles, such as PLGA nanoparticles, including polymeric core and lipid shell.Generally, at least one of these active agents is an immunomodulator that increases or decreases the immunostimulatory response.In some embodiments, the particle includes two kinds of immunomodulators that increase the immune stimulation response and reduce the immunosuppression response.The particles can modify the targeted part of the transfer to the target cell.Methods for enhancing the immune response and treating diseases such as cancer using the compositions are also disclosed.本發明公開了納米顆粒組合物。該等納米顆粒組合物通常包括至少一種，優選地兩種或更多種活性劑，其中的一種爲負載到傳遞媒劑中、連接到傳遞媒劑表面和／或封閉在傳遞媒劑內的免疫調節化合物。該等傳遞媒劑可爲包括聚合核心和脂質殼層的納米脂質體凝膠或可生物降解聚合納米粒子，如PLGA納米粒子。通常，該等活性劑中的至少一種爲增加免疫刺激反應或减少免疫抑制反應的免疫調節劑。在一些實施例中，該粒子包括增加免疫刺激反應的免疫調節劑和减少免疫抑制反應的免疫調節劑兩種。該等粒子可修飾有改進到靶細胞的傳遞的靶向部分。還公開了使用該等組合物增强免疫反應和治療如癌症的疾病的方法。
