Immune function testing method, cancer patient screening method, cancer treatment effect prediction method, intracellular calcium ion concentration increasing agent, effector memory (EM) and effector (eff) selective function improving agent in tumor tissue, How to monitor the effects of cancer drugs
In the present invention, peripheral blood of a human subject is collected, and after applying an immunostimulant, the transition of calcium ion concentration in peripheral blood mononuclear cells (PBMC) or CD8 T cells is examined. When the calcium ion concentration in PBMC or CD8 T cells increases and then returns to the pre-stimulation state, it is judged that systemic immune function is decreased, and calcium in PBMC or CD8 T cells is applied after application of the immunostimulant. The present invention relates to a method for examining immune function, in which the immune function of the whole body is judged to be normal when the ion concentration is in an increasing trend.本発明は、ヒト被験者の末梢血を採取し、免疫刺激剤を適用後、末梢血単核球（ＰＢＭＣ）又はＣＤ８Ｔ細胞内のカルシウムイオン濃度の推移を検査し、免疫刺激剤の適用後に一過性にＰＢＭＣ又はＣＤ８Ｔ細胞内のカルシウムイオン濃度が上昇し、その後刺激前の状態に戻る場合に全身の免疫機能が低下していると判断し、免疫刺激剤の適用後にＰＢＭＣ又はＣＤ８Ｔ細胞内のカルシウムイオン濃度が上昇基調にある場合に全身の免疫機能は正常であると判断される、免疫機能の検査方法に関する。
