DENNIS, MARK S.,KARIOLIS, MIHALIS,KWAN, WANDA,SILVERMAN, ADAM P.,SWEENEY, ZACHARY K.,ZUCHERO, JOY YU
申请号：
CA3088157
公开号：
CA3088157A1
申请日:
2019.01.10
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure relates generally to Fc polypeptide dimers that contain a non-native transferrin receptor (TfR) binding site, do not substantially deplete reticulocytes in vivo, but retain binding to the Fcg receptor (FcgR). The present disclosure also relates to an Fc polypeptide dimer that contains a non-native site that specifically binds TfR on one of the Fc polypeptides； a modification or modifications on the Fc polypeptide containing the TfR-binding site that reduces FcgR binding when bound to TfR, where the other Fc polypeptide does not contain a TfR-binding site but retains FcgR binding.
