PUFFER, BRIDGET,CHANDLER, JULIAN,GERA, NIMISH,SHERIDAN, DOUGLAS L.,JINDAL, SIDDHARTH,TAMBURINI, PAUL P.
申请号：
CA3067247
公开号：
CA3067247A1
申请日:
2018.07.11
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The disclosure provides engineered polypeptides that specifically bind to human complement component C5 and/or serum albumin. The disclosure also provides fusion proteins comprising such engineered polypeptides, wherein such fusion proteins may be multivalent and multi- specific fusion proteins. The disclosure further provides nucleic acid molecules that encode such engineered polypeptides or fusion proteins, and methods of making such engineered polypeptides or fusion proteins. The disclosure further provides pharmaceutical compositions that comprise such engineered polypeptides or fusion proteins, and methods of treatment using such engineered polypeptides or fusion proteins.
