靶向B細胞成熟抗原之嵌合型抗原受體類农业专利-农业专业知识服务系统

发明人:: KUO, TRACY CHIA-CHIEN,郭　佳娟,CHAPARRO RIGGERS, JAVIER FERNANDO,加帕洛瑞格斯　杰维尔,加帕洛瑞格斯　傑維爾,SASU, BARBRA JOHNSON,沙苏　芭芭拉,沙蘇　芭芭拉,GALETTO, ROMAN,加列图　罗曼,加列圖　羅曼,BOLDAJIPOUR, BIJAN ANDRE,波达吉普　比杰,波達吉普　比傑,SOMMER,,郭佳娟,加帕洛瑞格斯杰维尔,加帕洛瑞格斯傑維爾,沙苏芭芭拉,沙蘇芭芭拉,加列图罗曼,加列圖羅曼,波达吉普比杰,波達吉普比傑

摘要：: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).本發明提供特異結合B細胞成熟抗原(BCMA)之嵌合型抗原受體類(CARs)。本發明進一步關於包含該等CAR之經遺傳工程處理的免疫細胞、編碼CAR之核酸及製造該等CAR、經遺傳工程處理之免疫細胞和核酸之方法。本發明進一步關於使用這些CAR及經遺傳工程處理之免疫細胞來治療與表現BCMA之惡性細胞相關的病症(例如癌症)之治療方法。