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2-酰氨基噻唑化合物晶體
专利权人:
Astellas Pharma Inc.
发明人:
SUGASAWA, Keizo,MIYAFUJI, Akio,SUZUKI, Kenichi,AWAMURA, Yuji
申请号:
HK18106465.3
公开号:
HK1246793A
申请日:
2018.05.18
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
The purpose of the present invention is to provide crystals of 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexyl piperazin-1-yl) thiazol-2-yl] carbamoyl} pyridin-2-yl) piperidine-4-carboxylic acid maleic acid salt that can ensure constant quality and constant effects as a drug substance for medicines, and that can be stably supplied in mass production such as industrial production. The present invention relates to crystals of 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexyl piperazin-1-yl) thiazol-2-yl] carbamoyl} pyridin-2-yl) piperidine-4-carboxylic acid maleic acid salt with endothermic peak top temperatures in differential scanning calorimeter analysis of between approximately 229 and 232 degree C, and between approximately 300 and 303 degree C. The crystals of the present invention are with excellent oral absorption, can be stably supplied in mass production such as industrial production or the like, and can be used as an active ingredient in a pharmaceutical composition for preventing and/or treating various types of thrombocytopenia.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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