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Quinolyl-Containing Hydroxamic Acid Compound, Method for its Preparation, Pharmaceutical Composition Containing This Compound and Its Use
专利权人:
ЛТД. (CN);БЕЙДЖИН КОНРУНС ФАРМАСЬЮТИКАЛ КО.
发明人:
ЮНЬ Цзывэй (CN),ВАН Хонтао (CN)
申请号:
RU2014112345/04
公开号:
RU2014112345A
申请日:
2011.09.27
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A quinolyl-containing hydroxamic acid compound having a molecular structure of formula (I) wherein each of V and V is independently hydrogen, halogen, a group —OCF, —CF, —NO, —CN, —OH, —NH, —NMe, C1-6alkyl, Salkenyl , Alkynyl, cycloalkyl, heteroalicyclic, alkoxy, cycloalkyloxy or heteroalicycloxy; one of R and R ′ is a group Q containing hydroxamic acid, and the other is hydrogen, methoxy, methoxyethoxy or a group Q containing hydroxamic acid, where a group Q containing hydroxamic acid, representing and the formula A represents O, NH, S (= O), C1-6alkyl, or A is absent, and the hydrogen in A may be substituted by G; L is C1-6alkyl, C1-6alkenyl, C1-6alkynyl, Cycloalkyl, Saryl, heteroaryl, heteroalicyclic, or L is absent, and the hydrogen in L may be substituted by G; J represents O, NH, S (= O), C1-6alkyl, Salkenyl, C1-6alkynyl, Cycloalkyl, Saryl, Heteroaryl, Heteroalicyclic, or J is absent, and the hydrogen in J may be substituted by G; X represents —C (═O) -, —S (O), C1-6alkyl, C1-6alkenyl, C1-6alkynyl, Cycloalkyl, Saryl, Gheteroaryl, Gheteroalicyclic, or X is absent, and hydrogen in X may be substituted with G; Y is C1-6alkyl, C1-6alkyl, C1-6alkynyl, Cycloalkyl, Saryl, Heteroaryl, heteroalicyclic, or Y is absent, and hydrogen in Y may be substituted with G; where each of G, G, G, G and G is independently H, -CN, -CF, -COH, halogen, C 1-6alkyl, Cycloalkyl, C2-6alkenyl, C 1-6nalkyl, Caryl, Heteroaryl, Cetheroalicyclic, RO-, RRN-, RS (= O) -, RRNS (= O) -, RC (= O) -, RRNC (= O) -, ROC (= O) -, RC (= O) O-, RRNC (= O) O-, RC (= O) NR-, RRNC (= O) NR-, ROC ( = O) NR-, RS (= O) NR-, RRNS (= O) NR-, RRNC (= NR) NR-, RRNC (= CHNO) NR-, RRNC (= N-CN) NR-, RRNC ( = NR) -, RS (= O) (= NR) NR- or RRNS (= O) (= NR) -; each of R, R, R, R and R independently represents H, C1-6alkyl, Salkenyl, C1-6alkyl, Cycloalkyl, WITH1. Хинолилсодержащее соединение гидроксамовой кислоты, имеющее молекулярную структуру формулы (I)где каждый из Vи Vнезависимо представляет собой водород, гало
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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