PROBLEM TO BE SOLVED: To provide a nonaqueous composition containing adipose particles holding a medicament, and having such merits as being usable as an injection, an eye drop, a nasal drop, an inhalation or the like, and enabling a medicament-containing adipose emulsion having transparency and excellent stability to be prepared by being mixed with an aqueous medium at the time of use and to provide a method for producing the nonaqueous composition.SOLUTION: The nonaqueous composition containing the adipose particles holding the medicament is a medicament-containing adipose emulsion containing the slightly water-soluble medicament, an oil-and-fat, an emulsifier and water at least as the constituent components. The nonaqueous composition is obtained by allowing a water-soluble carrier to carry the adipose particles holding the medicament contained in the medicament-containing adipose emulsion regulated so that the content of the oil-and-fat may be 0.05-2 mg/mL, the weight ratio (medicament/oil-and-fat) of the medicament to the oil-and-fat may be 0.0005-50 (with the proviso that the total content of the medicament and the oil-and-fat is 10 mg/mL at the maximum), and the weight ratio (emulsifier/oil-and-fat) of the emulsifier to the oil-and-fat may be 1-300, in a state in which an aqueous phase is substantially removed.COPYRIGHT: (C)2011,JPO&INPIT【課題】 注射剤や点眼剤や点鼻剤や吸入剤などとして用いることができる、透明性を有するとともに安定性に優れる薬物含有脂肪乳剤を、用時に水系媒体と混合することで調製することができるといった利点を備える、薬物を保持した脂肪粒子を含む非水系組成物およびその製造方法を提供すること。【解決手段】 本発明の薬物を保持した脂肪粒子を含む非水系組成物は、水難溶性薬物、油脂、乳化剤、水を少なくとも構成成分とする薬物含有脂肪乳剤であって、油脂の含量が0.05~2mg/mL、油脂に対する薬物の重量比率(薬物/油脂)が0.0005~50(但し薬物と油脂の合計含量は最大で10mg/mL)、油脂に対する乳化剤の重量比率(乳化剤/油脂)が1~300である薬物含有脂肪乳剤に含まれる薬物を保持した脂肪粒子を、水相が実質的に除去された状態で水溶性担体に担持させてなることを特徴とする。【選択図】 なし
