PROBLEM TO BE SOLVED: To provide a composition for medicine or cell culture which is effective in maintenance or proliferation of a cell, protection of a stem cell from influence of irradiation, chemotherapy or the like, suppression of cell apoptosis, acceleration of cell migration, or functional recovery of ischemic tissue.SOLUTION: A composition for medicine or cell culture contains: chimeric protein containing a fibroblast growth factor 1 (FGF1) and a cell permeable peptide (CPP-C) including an amino acid sequence of a cell permeable domain which exists in a C terminal region of FGF11 to 14 or a specific amino acid sequence in which amino acid of a part of the amino acid sequence is substituted； or a DNA molecule including a DNA sequence which codes the chimeric protein or a vector including a DNA sequence which codes the chimeric protein.SELECTED DRAWING: None【課題】細胞の維持又は増殖、放射線照射や化学療法等による影響からの幹細胞の防護、細胞のアポトーシスの抑制、細胞の遊走の促進、又は虚血性組織の機能回復に有効な医薬用又は細胞培養用組成物の提供。【解決手段】維芽細胞増殖因子１（ＦＧＦ１）と、ＦＧＦ１１～１４のＣ末端領域に存在する膜透過ドメインのアミノ酸配列、又は該アミノ酸配列の一部のアミノ酸が置換され、且つ特定のアミノ酸配列を含む膜透過ペプチド（ＣＰＰ－Ｃ）、とを含むキメラタンパク質、又は該キメラタンパク質をコードするＤＮＡ配列を含むＤＮＡ分子、該キメラタンパク質をコードするＤＮＡ配列を含むベクターを含有する医薬用又は細胞培養用組成物。【選択図】なし
