The present invention provides an hnRNP A2* protein, nucleic acid for coding the protein and a use thereof. The protein contains a protein, a protein segment or a protein analog or derivative having an amino acid sequence shown as SEQ ID NO. 1. The hnRNP A2* protein can actively unloosen telomere G-quadruplexes, bind the minimum binding site at the 3 tail end of telomere, expose five nucleotide tails which can be matched with a telomere enzyme RNA template and promote the extension of telomere under the effect of telomere enzyme, thereby maintaining the cell division potential.
