Provided is a therapeutic drug for diseases associated with central nervous system (CNS) and/or peripheral nervous system (PNS) cholinergicity, diseases associated with smooth muscle contraction, endocrine diseases, diseases associated with neurodegeneration, and the like, said therapeutic drug having strong α7 nicotinic acetylcholine receptor (α7 nAChR)-regulating activity and that contains a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In formula (I), A is CR1E or a nitrogen atom, X-Y-Z is N-CO-NR3AR3B, or the like, R1A through R1E are the same or different and represent hydrogen atoms, or the like, R2A through R2D are the same or different and represent hydrogen atoms, or the like, R3A and R3B are the same or different and represent optionally substituted C3-10 cycloalkyls, or the like, and n is 1 or 2.].Un medicamento para el tratamiento de enfermedades asociadas con propiedades colinérgicas en el sistema nervioso central (SNC) y/o sistema nervioso periférico (SNP), enfermedades asociadas con la contracción del músculo liso, trastornos endocrinos, trastornos neurodegenerativos y similares, que comprende un compuesto de fórmula (I): (ver Fórmula) en donde A es CR1E o un átomo de nitrógeno, X-Y-Z es N-CO-NR3AR3B , lo similar, R1A a R1E son cada uno independientemente un átomo de hidrógeno y lo similar, R2A a R2D son cada uno independientemente un átomo de hidrógeno y lo similar, R3A y R3B son cada uno independientemente un cicloalquilo de C3-10 opcionalmente sustituido y lo similar y n es 1 ó 2 o una sal farmacéuticamente aceptable del mismo, que exhibe potentes efectos moduladores sobre la actividad del receptor nicotínico de la acetilcolina a7 (a7 nAChR).
