Rajan Gupta,Suliman F. Chawdry,Srinivas S. Duggirala
申请号：
US15066726
公开号：
US20170224666A9
申请日:
2016.03.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Immediate-release formulations for oral administration of a thrombin receptor antagonist are provided. Certain formulations of higher API loading demonstrate sufficient moisture uptake after storage at stressed conditions to retard dissolution. The formulations of the present invention incorporate either lower API loading or elevated disintegrant-to-API ratios, found necessary to achieve disintegration rates required for immediate-release performance.
