William J. McBride,Kristell L.S. Chatalic,Marion Hendriks-de Jong,Otto C. Boerman,David M. Goldenberg
申请号：
US14599816
公开号：
US20150217006A1
申请日:
2015.01.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present application discloses compositions and methods of synthesis and use of 18F-, 19F- or 68Ga-labeled molecules of use in PET, SPECT and/or MRI imaging of prostate cancer. Preferably, the 18F, 19F or 68Ga is attached to a chelator moiety on a prostate cancer targeting molecule, more preferably a bombesin analog, more preferably a GRPR antagonist, most preferably JMV5132 or JMV4168. The 18F or 19F may form a complex with a group IIIA metal to promote binding to the chelators. The labeled molecules may be used to detect, diagnose and/or image prostate cancer, including metastatic prostate cancer, in vivo.
