DES MACROPHAGES INGÈRENT LES CELLULES CANCÉREUSES EN UTILISANT LEUR PROPRE CALRÉTICULINE EN TANT QUE GUIDE

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专利权人:

The Board of Trustees of The Leland Stanford Junior University

发明人:

WEISSMAN, Irving L.,FENG, Mingye,VOLKMER, Jens-Peter

申请号：

EP16740762

公开号：

EP3247464A4

申请日:

2016.01.21

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated programmed cell removal (PrCR), the methods comprising increasing PrCR by contacting a phagocytic cell with a toll-like receptor (TLR) agonist； or down-regulating PrCR by contacting a phagocytic cell with an inhibitor of Bruton's tyrosine kinase (BTK). In some embodiments, an activator of TLR signaling or a BTK agonist is provided in combination with CD47 blockade.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/